Eliminating Vascular Obstruction in Myocardial Infarction by Accelerated Ferromagnetic Microrobot

Abstract

<title>Abstract</title> Background vascular obstruction by clots is one of the main reasons of cardiovascular disease such as myocardial infarction. There is a short time, less than 6 minutes, to establish the blood flow, especially in vital organs. While conventional techniques are not very fast and effective, current micro-robots have inherent limitations such as being slow to achieving this goal. Objective There is a strong requirement to develop microrobots with new principles that can quickly eliminate clot blockage in the vascular. The aim of this study is to evaluate, <italic>in-vitro</italic>, the efficiency of accelerated ferromagnetic micro-robots in destroying blood clots in an artificial vascular precipitately. Methods An artificial graft with a diameter of 10 mm were used as the vessel. Blood clots with various lengths (5*10 and 10*10 and 20*10mm³ (dimeter*length)) are formed inside the graft. Microrobots made of steel with a length of 1 mm and a width of 0.05 mm are utilized. Besides, an electromagnetic accelerator is prototyped to instantly raise the magnetic field, which accelerates the magnetic micro-robot toward the blocked artery. Blood clots with various lengths (5*10 and 10*10 and 20*10mm³(Dimeter*length)) are formed inside the tube. The effect of voltage from 100 to 400 volts on destroying different lengths of clot has been studied. Results The microrobot enables to destroy the clot and reopen the vessel in a fraction of a second. By increasing the voltage from 100 to 400 volt, the micro-robot is able to destroy clots with longer lengths from 5 to 30 mm. Conclusion results confirm that accelerated microbes have a unique potential in piercing clots to reestablish blood flow.