A comprehensive and flexible approach to the automated-dissolution testing of pharmaceutical drug products incorporating direct UV-vis fiber-optic analysis, on-line fluorescence analysis, and off-line storage options

Abstract

An automated system for on-line determination of the dissolution rates of drug-delivery formulations to USP Methods I and II is described. The system employs UV–vis spectroscopy utilizing either a fiber-optic probe for direct determination or the option of on-line flow through analysis with prior filtration. The system is also capable of on-line flow through analysis utilizing both UV–vis and fluorescence detection and an off-line storage option for further sample processing. The system also comprises a complete IT solution including a simple user interface, data archival to an NT server, remote client server interrogation of the database, and automatic report generation. © 2000 John Wiley & Sons, Inc. Lab Robotics and Automation 12:12–22, 2000