Validation of 3D reconstructions of a mimicked femoral artery with an ultrasound imaging robotic system

Abstract

PURPOSE: The degree of stenosis is the most important criterion to assess peripheral arterial disease manifested by atherosclerosis mainly in lower limb arteries. Ultrasound (U.S.) imaging offers low-cost, safe, and convenient options to evaluate this disease, but most U.S. freehand approaches cannot optimally locate stenoses and map lower limb arterial geometries. A 3D-U.S. imaging robotic system that can control and standardize image acquisition by scanning typically encountered diseased arterial lower limb segments is presented and validated with phantoms. METHODS: A Z-phantom calibration procedure was used to characterize spatial transformation of the U.S. probe image plane for different clinical image acquisition settings. Moreover, the accuracy of the calibration transform to reconstruct a lower-limb-mimicking vessel geometry was evaluated with a vascular phantom. RESULTS: A 3D calibration precision of 0.47 +/- 0.27 mm was achieved. Reconstruction errors were less than 1.74 +/- 0.08 mm in all 3D vessel representations and the cross-sectional areas of each image section were close to those of gold standard phantom measures. The best reconstruction accuracy (smallest error) was 0.40 +/- 0.03 mm. CONCLUSION: Altogether, these results demonstrate the potential of the robotic scanner to adequately represent lower limb vessels for the clinical evaluation of stenoses.