The Introduction of High-Throughput Experimentation Methods for Suzuki–Miyaura Coupling Reactions in University Education

Abstract

Use of high-throughput experimentation is becoming common in industry. To prepare students to work with those novel techniques in their future careers, the utilization of an automated synthesis robot was integrated into an undergraduate research project. The practical course included performing a "classical" Suzuki–Miyaura coupling reaction in the laboratory, which was subsequently converted into a step-by-step procedure suitable for fully automated parallel synthesis robots. In a next step, the power of high-throughput experimentation was demonstrated by performing 16 automated parallel Suzuki–Miyaura coupling reactions, during which the influence of solvent and base on the reaction were investigated.