Process development

Miniature bioreactors: current practices and future opportunities.

Jonathan Ian Betts, Frank Baganz

引用数: 281 • 2006

Novel micro‐bioreactor high throughput technology for cell culture process development: Reproducibility and scalability assessment of fed‐batch CHO cultures

Ashraf Amanullah, José M. Otero, Mark Mikola, Amy Hsu, Jinyou Zhang, John Auniņš, H. Brett Schreyer, James A. Hope, Adele Russo

引用数: 110 • 2010

High-throughput downstream process development for cell-based products using aqueous two-phase systems

Sarah C. Zimmermann, Sarah Gretzinger, M. Schwab, Christian Scheeder, Philipp K. Zimmermann, Stefan A. Oelmeier, Eric Gottwald, Are Bogsnes, Mattias Hansson, Arne Staby

引用数: 26 • 2016

Accelerated recombinant protein purification process development

Tom Londo, Paul Lynch, Terry Kehoe, M Meys, Neal F. Gordon

引用数: 21 • 1998

PROCESS DEVELOPMENT IN MECHANICAL ENGINEERING: INNOVATIONS, CHALLENGES, AND OPPORTUNITIES

Adeniyi Kehinde Adeleke, Danny Jose Portillo Montero, Kehinde Andrew Olu-lawal, Oladiran Kayode Olajiga

引用数: 18 • 2024

Automated disposable small-scale bioreactor for high-throughput process development: implementation of the 24 bioreactor array

Rachel Bareither, Marina Goldfeld, C. Kistler, Andrew S. Tait, Neil Bargh, Robert Oakeshott, Kristin O'Neill, Linda Hoshan, David Pollard

引用数: 16 • 2015

A novel high-throughput process development screening tool for virus filtration

Alison Tang, Irina Ramos, Kelcy J. Newell, Kevin D. Stewart

引用数: 13 • 2020

Small, smaller, smallest: Miniaturization of chromatographic process development

Tiago Castanheira Silva, Michel H. M. Eppink, Marcel Ottens

引用数: 13 • 2022

Lessons learned in building high‐throughput process development capabilities

Jennifer M. Pollard, Paul C. McDonald, Ashley Hesslein

引用数: 11 • 2016

High‐throughput downstream process development for cell‐based products using aqueous two‐phase systems (ATPS) – A case study

Sarah C. Zimmermann, Christian Scheeder, Philipp K. Zimmermann, Are Bogsnes, Mattias Hansson, Arne Staby, Jürgen Hubbuch

引用数: 11 • 2016

Leveraging high‐throughput technology to accelerate the time to clinic: A case study of a mAb

Sethu Siva, An Zhang, Edward K. Koepf, Lynn Conley, Doug Cecchini, Yao‐ming Huang, Rashmi Kshirsagar, Thomas Ryll

引用数: 5 • 2015

High throughput screening of particle conditioning operations: I. System design and method development

Aaron Noyes, Ben Huffman, Ranga Godavarti, Nigel J. Titchener‐Hooker, Jon Coffman, Khurram Sunasara, Tarit Mukhopadhyay

引用数: 4 • 2015

Automated Conditional Screening of Escherichia Coli Knockout Mutants in Parallel Adaptive Fed-Batch Cultivations

Sebastian Hans, Benjamin Haby, Niels Krausch, Tilman Barz, Peter Neubauer, Mariano Nicolás Cruz Bournazou

引用数: 4 • 2020

High throughput chromatography and analytics can inform viral clearance capabilities during downstream process development for biologics

Krishana Gulla, Zachary J. Schneiderman, Sarah O’Connell, Gabriel F. Arias, Nicole Cibelli, David Cetlin, Daniel B. Gowetski

引用数: 3 • 2021

Robotic Process Automation of office work: benefits, challenges and capability development

Kristian Strömberg

引用数: 3 • 2018

The SimcellTM High-Throughput Cell Culture System: An Automated Approach to Integrated Cell Line Selection and Process Development

Steve Warr, Yuen-Ting Chim, Adele Russo, Brian Benoit, Mark Uden

引用数: 2 • 2011

AI-enhanced radioactive particle tracking: A practical methodology for accelerating industrial process development

Ghazaleh Mirakhori, Jocelyn Doucet, Saad Chidami, Bruno Blais

引用数: 1 • 2025

Stick to the beads: supercharging medicinal chemistry and methodology development with ChemBeads

Noah P. Tu, Ying Wang

引用数: 1 • 2025