Smallest real differences for robotic measures of upper extremity function after stroke: Implications for tracking recovery

摘要

INTRODUCTION: Measurements from upper limb rehabilitation robots could guide therapy progression, if a robotic assessment's measurement error was small enough to detect changes occurring on a time scale of a few days. To guide this determination, this study evaluated the smallest real differences of robotic measures, and of clinical outcome assessments predicted from these measures. METHODS: A total of nine older chronic stroke survivors took part in 12-week study with an upper-limb end-effector robot. Fourteen robotic measures were extracted, and used to predict Fugl-Meyer Assessment-Upper Extremity (FMA-UE) and Action Research Arm Test (ARAT) scores using multilinear regression. Smallest real differences and intraclass correlation coefficients were computed for the robotic measures and predicted clinical outcomes, using data from seven baseline sessions. RESULTS: Smallest real differences of robotic measures ranged from 8.8% to 26.9% of the available range. Smallest real differences of predicted clinical assessments varied widely depending on the regression model (1.3 to 36.2 for FMA-UE, 1.8 to 59.7 for ARAT), and were not strongly related to a model's predictive performance or to the smallest real differences of the model inputs. Models with acceptable predictive performance as well as low smallest real differences were identified. CONCLUSIONS: Smallest real difference evaluations suggest that using robotic assessments to guide therapy progression is feasible.