Verifying global identifiability of parametric linear ODE models is NP-hard

摘要

Global parameter identifiability is a property of a parametric ODE model to recover the parameter values uniquely from the input-output data. Not all parametric ODE models have this property, and checking for parameter identifiability is a prerequisite to perform numerical parameter estimation. There are many algorithms and software packages for global parameter identifiability, and frequently the runtime is large. However, the computational complexity for this problem has not been analyzed yet, though there are complexity results for local (finitely many values fit the data) parameter identifiability. In this paper, we estimate the complexity of checking global parameter identifiability over real fields for ODE models that depend linearly on the state variables and rationally on the parameters. In particular, we prove that it is equivalent to the injectivity problem.