Yuchen Fan
Papers
2
Total Citations
95
H-Index
2
About
Yuchen Fan is a leading researcher in the field of nanomedicine, with a primary focus on the rational design and characterization of lipid nanoparticle (LNP) systems for nucleic acid delivery. Fan’s work is distinguished by a deep integration of formulation science and advanced biophysical characterization, driving the development of more efficient and scalable LNP platforms. A major contribution is the development of an automated, high-throughput platform for preparing and characterizing oligonucleotide-loaded LNPs, a seminal work that has garnered 63 citations for its potential to accelerate preclinical screening. Further advancing the field, Fan’s investigation into the impact of non-ionizable lipids and phase mixing methods on LNP structural properties (32 citations) has provided critical insights into how formulation parameters dictate particle architecture and performance. By systematically deconstructing the roles of lipid composition and processing, Fan’s research is paving the way for more rational and reproducible LNP design, directly impacting the development of next-generation RNA therapeutics and vaccines.
Research Focus
Key Achievements
Top Papers
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