Yi Xiao

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About

Yi Xiao is a prominent researcher specializing in aptamer science and nucleic acid biotechnology, with a particular focus on developing innovative methods for aptamer characterization, engineering, and biosensing applications. Her work centers on leveraging the unique properties of single-stranded nucleic acids — molecules selected through the SELEX (Systematic Evolution of Ligands by Exponential Enrichment) process — to create highly specific molecular recognition tools for diagnostics and therapeutics. Among her most notable contributions is the development of exonuclease-based approaches to advance aptamer research. Her 2023 Conspectus paper, "Using Exonucleases for Aptamer Characterization, Engineering, and Sensing," has already garnered 53 citations, reflecting its significant influence on the field. Complementing this, her 2022 study introducing a high-throughput quantitative binding analysis method for DNA aptamers — cited 24 times — addressed a critical bottleneck in identifying optimal aptamers for real-world applications, offering researchers a powerful new analytical framework. Xiao's research has meaningful implications for medical diagnostics and therapeutic development, where precise molecular binding is paramount. Her innovative methodologies have helped establish new standards in aptamer evaluation, making her a key figure in advancing nucleic acid-based biotechnology.