Yen-Hong Kuo

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About

Yen-Hong Kuo is a pathologist whose research focuses on improving diagnostic accuracy and surgical decision-making in gynecologic oncology, particularly endometrial cancer and its precursors. Her work addresses critical challenges in intraoperative evaluation, where rapid pathology assessments guide lymph node dissection. In her highly cited 2020 study (10 citations), Kuo systematically examined the limitations of applying the Mayo Clinic criteria—histopathology, grade, tumor size, and myometrial invasion depth—during frozen section analysis, revealing significant obstacles to reliable risk stratification. This contribution has helped refine clinical protocols and highlighted areas needing improved diagnostic tools. More recently, her 2024 investigation into sentinel lymph node sampling for complex atypical endometrial hyperplasia (3 citations) tackles a pressing clinical dilemma: patients with CAH face a high probability of underlying cancer, yet intraoperative evaluation remains unreliable. By validating the safety and sensitivity of SLN sampling in this population, Kuo’s work supports more precise, less invasive surgical management. Her research bridges pathology and surgical oncology, offering evidence-based guidance that directly impacts patient outcomes. Kuo’s careful, problem-oriented approach makes her a valuable voice in the ongoing effort to standardize and improve endometrial cancer care.