Yau Yi Lau
Papers
2
Total Citations
109
H-Index
2
About
Yau Yi Lau is a pioneering researcher in the field of bioanalytical chemistry and drug discovery, with a focus on high-throughput mass spectrometry methodologies. Her major contributions center on the development of automated, rapid techniques for pharmacokinetic screening, particularly in plasma protein binding and metabolic stability assays. In her seminal 2003 work, she introduced a semi-automatic, 96-well plate filtrate assembly coupled with fast liquid chromatography–tandem mass spectrometry (LC/MS/MS) for high-throughput determination of plasma protein binding—a method that has garnered 71 citations for its efficiency and reproducibility. Building on this, her 2004 study (38 citations) advanced automatic mass spectrometry method development for metabolic stability assays, addressing the critical need for high-throughput screening in drug discovery. By streamlining LC/MS/MS with fast gradients, Lau’s innovations significantly accelerated the pace of metabolic screening, enabling routine analysis alongside high-throughput organic synthesis. Her work has been instrumental in bridging the gap between analytical chemistry and pharmaceutical development, providing robust, scalable solutions that have been widely adopted in drug metabolism and pharmacokinetics (DMPK) laboratories. Lau’s contributions remain foundational for researchers seeking to optimize early-stage drug candidate evaluation.
Research Focus
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Top Papers
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