Yanmei Guo

Papers

Total Citations

184

H-Index

About

Yanmei Guo is a leading figure in synthetic biology and metabolic engineering, best known for pioneering advanced genome editing tools in industrial microorganisms. Her most impactful work centers on the development of MACBETH (Multiplex Automated Corynebacterium glutamicum Base Editing Method), a groundbreaking platform that enables efficient, multiplexed base editing in *Corynebacterium glutamicum*—a workhorse bacterium for amino acid and biochemical production. This 2018 study, which has garnered 184 citations, revolutionized strain engineering by allowing simultaneous, precise modifications without double-strand breaks, dramatically accelerating the design of high-yielding microbial cell factories. Guo’s contributions have reshaped the field of microbial genome editing, offering a scalable and automatable approach that bridges the gap between fundamental research and industrial application. Her work is widely recognized for its technical elegance and practical impact, empowering researchers to rapidly engineer complex metabolic pathways. Through MACBETH and related innovations, Yanmei Guo has established herself as a key architect of next-generation synthetic biology tools, driving progress toward sustainable biomanufacturing and precision fermentation.