Papers
1
Total Citations
22
H-Index
1
About
Xiaoqing Shi is a distinguished researcher whose work has significantly advanced the field of drug discovery, particularly in the development of high-throughput screening assays for G protein-coupled receptors (GPCRs). Her key research areas include assay development, receptor pharmacology, and ultra-high-throughput screening technologies. Shi’s most notable contribution is the development of a groundbreaking 1,536-well [³⁵S]GTPγS scintillation proximity binding assay for ultra-high-throughput screening of an orphan Gαi-coupled GPCR. This work, published in 2008 and cited 22 times, revolutionized the screening process by enabling the simultaneous testing of thousands of compounds, dramatically accelerating the identification of potential therapeutic agents targeting GPCRs—a class of receptors implicated in numerous diseases. Her innovative approach has had a lasting impact on pharmaceutical research, providing a robust and scalable method for studying orphan receptors. Shi’s achievements underscore her expertise in bridging assay miniaturization with functional receptor studies, making her a pivotal figure in the quest to unlock the therapeutic potential of GPCRs.
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