Papers
4
Total Citations
115
H-Index
4
About
William Yaxley is a leading urological researcher whose work has fundamentally advanced the diagnosis and surgical management of prostate cancer. His primary research focus lies in comparing the predictive accuracy of preoperative imaging modalities—specifically multiparametric magnetic resonance imaging (mpMRI) and gallium-68 prostate-specific membrane antigen PET/CT (PSMA PET/CT)—against gold-standard histopathology from radical prostatectomy specimens. Yaxley’s landmark 2020 study, cited 69 times, demonstrated that PSMA PET/CT outperforms mpMRI in predicting pathological outcomes such as extraprostatic extension and lymph node involvement. His subsequent 2021 analysis of over 1,100 men (33 citations) revealed that PSMA PET/CT identifies clinically significant cancers missed by mpMRI, reshaping diagnostic and staging protocols. Yaxley has also contributed to surgical innovation, detailing a robot-assisted “W” ileal neobladder technique for urinary diversion. Notably, his work on totally embedded prostatectomy specimens has challenged the reliability of negative mpMRI findings, showing that a substantial proportion of low-risk lobes harbor occult cancer. With over 100 cumulative citations, Yaxley’s research bridges radiology, pathology, and surgery, providing clinicians with evidence to optimize patient selection for biopsy and treatment, ultimately improving outcomes for men with prostate cancer.
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