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About

John Yaxley is a leading urological surgeon and researcher whose work has fundamentally shaped our understanding of surgical approaches to prostate cancer treatment and staging. Best known for his landmark randomised controlled trial comparing robot-assisted laparoscopic prostatectomy with open radical retropubic prostatectomy, Yaxley's phase 3 study and its 24-month follow-up have collectively amassed over 1,150 citations, making them among the most influential contributions to urological oncology in the past decade. These trials provided the field with rigorous, high-quality evidence in an area long dominated by observational data and institutional preference. Beyond surgical technique, Yaxley has made substantial contributions to prostate cancer imaging and staging, particularly through his work integrating ⁶⁸Ga-PSMA PET/CT and multiparametric MRI into preoperative assessment. His research developing and validating novel nomograms for predicting pelvic lymph-node metastases — incorporating cutting-edge molecular imaging — has directly influenced surgical decision-making around extended pelvic lymph-node dissection. His large histopathological study in over 1,100 men further reinforced the complementary diagnostic value of these modalities. Spanning brachytherapy, open prostatectomy, and advanced imaging, Yaxley's body of work reflects a career committed to evidence-based, patient-centred prostate cancer care.