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About

Wilhelm den Toom is a leading researcher in the field of stereotactic body radiation therapy (SBRT), with a particular focus on advancing robotic radiosurgery for complex and challenging anatomical sites. His work centers on treatment planning optimization, online adaptive radiotherapy, and the integration of artificial intelligence into clinical decision-making. Den Toom’s major contributions include demonstrating how novel optimizers like VOLO™ can dramatically reduce organ-at-risk doses while improving planning and delivery efficiency for robotic SBRT cases, as shown in his 2021 study. He has also pioneered technical feasibility studies for online adaptive stereotactic treatments in the abdomen, addressing the critical issue of inter-fraction motion. His most cited work, “Treatment planning for spinal radiosurgery” (2018, 35 citations), remains a foundational reference in the field. Notably, den Toom has developed an AI-based clinical decision-making tool that predicts dosimetric outcomes for uveal melanoma patients, enabling rapid selection between stereotactic radiation therapy and proton therapy. His research on inter- and intrafraction dose variations in the prospective phase I STRONG trial for perihilar cholangiocarcinoma further underscores his commitment to improving precision and safety in SBRT, making him a key figure in modern radiation oncology.