Weiguo Dai
Papers
3
Total Citations
141
H-Index
3
About
Weiguo Dai is a leading figure in pharmaceutical formulation science, whose work has fundamentally advanced the oral delivery of poorly water-soluble drugs. His research focuses on the critical challenge of drug precipitation—a major barrier to bioavailability—and he has pioneered innovative strategies to overcome it. Dai’s most influential contribution is the development of a combination approach using solubilization agents and precipitation inhibitors, a method that directly addresses the problem of weakly basic compounds precipitating in the small intestine after gastric emptying. This work, published in a 2012 study (41 citations), provides a practical, case-based solution for enhancing the bioavailability of challenging drug candidates. Earlier, in 2007 (65 citations), he identified the potential of Pluronic/Vitamin E TPGS as a precipitation inhibitor, a finding that has become a cornerstone in formulation design. His 2006 paper (35 citations) introduced a parallel screening approach that allows researchers to identify solubility-enhancing formulations using only milligram quantities of material, dramatically accelerating early-stage drug development. With over 140 citations across his key works, Dai’s research is essential reading for anyone tackling the formulation of poorly soluble compounds, offering both mechanistic insight and actionable tools for improving therapeutic outcomes.
Research Focus
Key Achievements
Top Papers
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