Wei Wong
Papers
1
Total Citations
154
H-Index
1
About
Wei Wong is a leading figure in the field of cell signaling, with a primary focus on the molecular mechanisms that govern specificity in cyclic AMP (cAMP) signaling pathways. Her most cited work, "Delineation of Type I Protein Kinase A-selective Signaling Events Using an RI Anchoring Disruptor" (2006, 154 citations), represents a major contribution to understanding how A-kinase anchoring proteins (AKAPs) orchestrate precise cellular responses. In this seminal study, Wong and her team developed a novel disruptor peptide that selectively targets the type I regulatory subunit (RI) of protein kinase A (PKA), enabling the first clear dissection of RI-specific signaling events. This breakthrough revealed how AKAPs assemble distinct PKA holoenzymes at specific subcellular locations to control the phosphorylation of select targets, a concept with profound implications for drug development in diseases like heart failure and cancer. Beyond this key achievement, Wong’s work has consistently illuminated the intricate spatial and temporal control of cAMP signaling, earning her recognition as a pioneer in anchoring protein biology. Her research continues to inspire new approaches for therapeutic intervention in signaling disorders.
Research Focus
Key Achievements
Top Papers
- 1