Naoto Hoshi
Papers
1
Total Citations
154
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1
About
Naoto Hoshi is a leading figure in cellular signaling, whose work has fundamentally advanced our understanding of how specificity is achieved in cAMP-dependent pathways. His research focuses on the molecular mechanisms of protein kinase A (PKA) signaling, particularly the role of A-kinase anchoring proteins (AKAPs) in orchestrating localized cellular responses. Hoshi’s major contribution includes the development of a novel RI anchoring disruptor, a tool that allowed him to delineate Type I PKA-selective signaling events for the first time. This seminal work, published in 2006 and cited over 150 times, revealed how AKAPs tether PKA holoenzymes to specific subcellular compartments, ensuring that only select substrates are phosphorylated. By demonstrating that disrupting this anchoring can abolish specific signaling outcomes, Hoshi provided critical insight into the spatial control of kinase activity—a concept with profound implications for drug discovery and the treatment of diseases like heart failure and neurological disorders. His findings have helped shape modern views of signal compartmentalization, establishing him as a key architect in the field of cAMP signaling.
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