Wayne F. Patton
Papers
3
Total Citations
401
H-Index
3
About
Wayne F. Patton is a pioneering researcher in proteomics and fluorescence-based detection technologies, whose work has significantly advanced the field of protein analysis and visualization. His research sits at the critical intersection of biochemistry, imaging technology, and high-throughput proteomics, with a particular focus on developing and refining methods for detecting and quantifying proteins in complex biological samples. Patton's most celebrated contribution, "A Thousand Points of Light" (2000), garnered an impressive 329 citations and addressed fundamental challenges in two-dimensional gel electrophoresis — a cornerstone technique in proteomics. His work tackled key technical limitations of the era, championing fluorescent dye technologies that offered superior sensitivity, broader linear dynamic range, and greater compatibility with downstream analytical methods compared to conventional approaches. His complementary work on automated proteomics, "Making Blind Robots See" (2000), further demonstrated his vision for integrating fluorescent detection systems with imaging devices to enable truly high-throughput protein expression analysis. By exploring how proteins are synthesized, degraded, modified, and distributed within cells, Patton helped lay the conceptual and technical groundwork for modern proteomics workflows. His contributions remain essential reading for researchers navigating protein detection and quantitation challenges.
Research Focus
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