Tiziana Cotrufo
Papers
2
Total Citations
31
H-Index
2
About
Tiziana Cotrufo is a leading computational biologist whose research focuses on the molecular mechanisms driving liquid-liquid phase separation (LLPS)—a fundamental process governing the formation of membraneless organelles in cells. Her major contributions center on developing state-of-the-art predictive tools that decode how proteins undergo phase separation, a phenomenon increasingly linked to cellular organization and human diseases. Cotrufo’s landmark work, culminating in the catGRANULE 2.0 ROBOT algorithm (2025, 27 citations), represents a significant leap forward by integrating physicochemical properties with AlphaFold-derived structural features to predict LLPS propensity at single amino acid resolution. This builds on her earlier foundational model (2024, 4 citations), which established the framework for pinpointing critical protein regions driving phase behavior. Her tools empower researchers to identify phase-separating proteins with unprecedented accuracy, offering vital insights into neurodegenerative disorders and cancer. Cotrufo’s innovative approach bridges computational biology and structural prediction, making her a pivotal figure in understanding cellular compartmentalization and its dysregulation in disease.
Research Focus
Key Achievements
Top Papers
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