Thierry Langer

Papers

Total Citations

170

H-Index

About

Thierry Langer is a distinguished computational chemist and medicinal researcher whose work has profoundly shaped the field of computer-aided drug discovery, with a particular focus on natural product research and pharmacophore-based methodologies. His expertise lies at the intersection of cheminformatics, virtual screening, and the identification of bioactive compounds from natural sources. Langer's most influential contribution centers on pioneering the application of virtual screening to natural product drug discovery, a landmark 2007 survey that has garnered over 160 citations and remains a foundational reference in the field. This work addressed the critical challenge of navigating the rapidly expanding landscape of secondary metabolites against a growing number of therapeutically relevant molecular targets — a problem of enormous practical significance in modern drug development. Complementing this, his research on pharmacophore-based screening has demonstrated concrete, successful pathways for identifying bioactive natural products through computational approaches, helping bridge the gap between computational prediction and experimental validation. Together, these contributions have helped establish virtual screening as an indispensable tool in natural product-driven drug discovery, influencing how researchers worldwide approach the identification of novel therapeutically active compounds from nature's vast chemical repertoire.