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About

Theresa Guo is a head and neck surgical oncologist whose research focuses on HPV-mediated oropharyngeal cancer and the management of cancers of unknown primary (CUP). Her work addresses two critical challenges in the field: optimizing outcomes for the rising tide of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC), which now accounts for 80–90% of oropharynx tumors, and improving detection and treatment for patients presenting with cervical metastases from an unknown primary site. Her highly cited 2022 review on recurrent HPV-mediated OPSCC (38 citations) provides essential perspectives on this prognostically favorable but clinically complex population. Her 2022 update on unknown primary management (29 citations) synthesizes advances in primary site detection, which is critical for targeted therapy and avoiding treatment morbidity. Guo’s 2023 study demonstrating early improved functional outcomes when primary tumors are identified, and her analysis of transoral surgery outcomes across the Veterans Affairs system, extend these insights into real-world, multi-institutional settings. Through this body of work, Guo is shaping evidence-based approaches to de-escalation, surgical management, and functional preservation in head and neck cancer.