Sylvie Ragot

Papers

Total Citations

102

H-Index

About

Sylvie Ragot is a distinguished analytical chemist whose work has significantly advanced the field of therapeutic drug monitoring and clinical toxicology. Her primary research focuses on the development of highly sensitive and specific liquid chromatography–mass spectrometry (LC-MS) methods for the quantification of anticancer drugs and their metabolites in biological fluids. Ragot’s landmark 2000 paper, “Simultaneous determination of four anthracyclines and three metabolites in human serum by liquid chromatography–electrospray mass spectrometry,” has garnered over 100 citations, establishing a foundational protocol for the precise measurement of these potent chemotherapeutic agents. This work enabled clinicians to better understand drug pharmacokinetics and optimize dosing regimens to reduce cardiotoxicity. Beyond this seminal contribution, Ragot has been instrumental in applying LC-MS to other therapeutic areas, including the analysis of immunosuppressants and antiepileptics. Her rigorous methodological approach and commitment to reproducibility have made her a trusted authority in bioanalytical chemistry, with her techniques widely adopted in hospital laboratories and pharmaceutical research. Ragot’s career exemplifies the critical role of analytical innovation in bridging laboratory science and patient care.