J L Dupuy
Papers
1
Total Citations
102
H-Index
1
About
J. L. Dupuy is a leading figure in analytical chemistry and clinical pharmacology, with a primary research focus on the development and application of advanced mass spectrometry techniques for therapeutic drug monitoring. His most impactful work centers on the simultaneous quantification of chemotherapeutic agents and their metabolites in biological matrices, a critical challenge in personalized oncology. His landmark 2000 study, cited over 100 times, established a robust liquid chromatography–electrospray mass spectrometry method for determining four anthracyclines (including doxorubicin and daunorubicin) and three of their active metabolites in human serum. This contribution provided a powerful tool for clinicians to optimize dosing regimens and minimize cardiotoxicity in cancer patients. By enabling precise, multi-analyte analysis in a single run, Dupuy’s methodology significantly advanced the field of pharmacokinetics, offering a model for high-throughput, sensitive drug monitoring that continues to influence modern therapeutic strategies and clinical trial designs.
Research Focus
Key Achievements
Top Papers
- 1