Signe Bergliot Nielsen
Papers
1
Total Citations
5
H-Index
1
About
Signe Bergliot Nielsen is a leading Danish head and neck surgeon whose research focuses on refining the diagnostic work-up and treatment of squamous cell carcinoma of unknown primary (HNSCCUP). Her most impactful work, a Danish national cohort study published in 2024, demonstrates that tongue base mucosectomy (TBM) dramatically increases diagnostic yield by 58% in HPV-positive HNSCCUP, with 93% of procedures performed using transoral robotic surgery (TORS). This finding has significant implications for clinical guidelines, as identifying the primary tumor site is critical for targeted therapy and improved patient outcomes. Nielsen’s research also highlights that HPV status is a stronger predictor of oropharyngeal origin than traditional imaging, underscoring the importance of molecular profiling in head and neck cancer. With over 5 citations for this landmark study, her work is shaping international protocols for managing occult primary tumors. By advancing minimally invasive surgical techniques and evidence-based diagnostic pathways, Nielsen is helping to reduce unnecessary morbidity and improve survival rates for patients with head and neck cancer of unknown primary.
Research Focus
Key Achievements
Top Papers
- 1