Shigeaki Yokoi
Papers
1
Total Citations
6
H-Index
1
About
Shigeaki Yokoi is a cancer geneticist whose research centers on the molecular mechanisms driving renal cell carcinoma, particularly the role of the Von Hippel-Lindau (VHL) tumor suppressor gene. His most cited work, "Derivative Chromosome 3 Loss from t(3;6)(q12;q14) Followed by Differential VHL Mutations Underlie Multifocal ccRCC" (2022), provides critical insight into how chromosomal rearrangements and subsequent VHL mutations cooperate to produce multifocal clear cell renal cell carcinoma (ccRCC). By demonstrating that derivative chromosome 3 loss from a specific translocation precedes and enables distinct VHL mutations in separate tumor foci, Yokoi’s research illuminates a stepwise model of tumor heterogeneity and clonal evolution. This work has garnered 6 citations, establishing a foundation for understanding how VHL’s role in HIFα degradation is disrupted in ccRCC. His contributions are significant for their mechanistic clarity, linking cytogenetic events to functional loss of pVHL and the resulting accumulation of HIFα that drives tumorigenesis. For students and researchers, Yokoi’s studies exemplify how combining cytogenetics with mutation analysis can unravel the complex, multifocal nature of kidney cancer, offering a framework for future therapeutic targeting of VHL-deficient tumors.
Research Focus
Key Achievements
Top Papers
- 1