Shane A. Seabrook
Commonwealth Scientific and Industrial Research Organisation
Papers
1
Total Citations
43
H-Index
1
About
Shane A. Seabrook is a leading figure in structural biology and biophysical chemistry, with a primary focus on the engineering and characterization of lipidic cubic phase (LCP) materials for membrane protein research. His most influential work centers on overcoming the technical challenges of handling highly viscous lipid systems, enabling high-throughput structural studies. In his landmark 2012 paper, "High-Throughput Production and Structural Characterization of Libraries of Self-Assembly Lipidic Cubic Phase Materials," Seabrook introduced a revolutionary protocol that leverages standard liquid dispensing robotics to produce libraries of lyotropic liquid crystalline phases from diverse lipid mixtures. This work, cited over 40 times, provided a critical solution for automating LCP preparation—a bottleneck in serial crystallography and drug discovery. By circumventing traditional viscosity-related obstacles, Seabrook’s contributions have accelerated the structural characterization of G protein-coupled receptors and other membrane proteins. His achievements underscore a commitment to methodological innovation, making him a key enabler of high-impact structural biology research.
Research Focus
Key Achievements
Top Papers
- 1