S. Sarati
Papers
1
Total Citations
60
H-Index
1
About
S. Sarati is a distinguished researcher in pharmaceutical bioanalysis and drug metabolism, with a primary focus on the quantitation of targeted cancer therapeutics. Her most cited work, a 2003 study on SU11248 (sunitinib), an oral multi-target tyrosine kinase inhibitor, exemplifies her expertise in developing robust liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods. This seminal paper, which has garnered 60 citations, details a semi-automated liquid-liquid extraction technique for measuring the drug and its active metabolite in monkey tissues, providing critical pharmacokinetic data that supported the preclinical development of a now-standard oncology agent. Sarati’s contributions are foundational to understanding the disposition of small-molecule kinase inhibitors, bridging analytical chemistry and translational pharmacology. Her methodical approach to bioanalytical validation has enabled precise drug quantification in complex biological matrices, directly impacting the safety and efficacy assessments of emerging therapies. Through this work, Sarati has established herself as a key figure in the advancement of targeted cancer drug development, offering invaluable tools for researchers and clinicians alike.
Research Focus
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