Chuqi Ye
Papers
1
Total Citations
60
H-Index
1
About
Chuqi Ye is a distinguished researcher in pharmaceutical analysis and drug metabolism, with a primary focus on the bioanalytical quantification of tyrosine kinase inhibitors. Their most cited work, a 2003 study on the quantitation of SU11248 (sunitinib) and its metabolite in monkey tissues, has garnered 60 citations, establishing a foundational methodology for the pharmacokinetic assessment of this critical oral multi-target cancer therapy. Ye’s major contribution lies in the development of a robust, semi-automated liquid-liquid extraction technique coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS), which enabled precise, high-throughput analysis of drug distribution in complex biological matrices. This work not only advanced the preclinical understanding of sunitinib’s tissue disposition but also set a standard for bioanalytical methods in targeted oncology drug development. By providing a reliable framework for quantifying both parent drug and active metabolite, Ye’s research has directly supported the translational safety and efficacy profiling of multi-kinase inhibitors, impacting subsequent clinical studies and therapeutic monitoring. Their meticulous approach to analytical chemistry continues to inform best practices in pharmaceutical bioanalysis.
Research Focus
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Top Papers
- 1