Ruifeng Cui

Papers

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About

Ruifeng Cui is a clinician-researcher whose work sits at the intersection of head and neck oncology and molecular diagnostics. His primary research focus is the application of liquid biopsy technologies—specifically, circulating tumor human papillomavirus DNA (ctHPVDNA)—to improve the detection and management of HPV-related oropharyngeal squamous cell carcinoma (OPSCC). In his most cited pilot study (2024, 10 citations), Cui investigated the diagnostic accuracy of ctHPVDNA assays in patients presenting with cervical neck masses of unknown primary origin, a common clinical challenge. This work demonstrated the potential of ctHPVDNA as a non-invasive, highly specific diagnostic tool to identify occult HPV-positive OPSCC, offering a promising alternative to invasive biopsies and reducing diagnostic delays. By validating this approach in a real-world cohort, Cui has contributed to a paradigm shift toward precision oncology in head and neck cancer care. His findings have been cited by subsequent studies exploring ctHPVDNA for treatment response monitoring and recurrence surveillance, underscoring his growing influence in the field. Cui’s research bridges the gap between translational science and clinical practice, positioning him as a rising expert in HPV-related cancer diagnostics.