Rosamaria Lappano
Papers
1
Total Citations
15
H-Index
1
About
Rosamaria Lappano is a leading researcher in the field of endocrine pharmacology, with a primary focus on the molecular mechanisms of estrogen receptor signaling and the development of novel therapeutic agents. Her major contributions lie at the intersection of structural biology and drug discovery, particularly in the design of selective estrogen receptor modulators (SERMs). In her highly cited 2011 work, "Structure-Based Approach for the Discovery of Novel Selective Estrogen Receptor Modulators," Lappano pioneered the use of protein crystallography and high-throughput structural analysis to rationally design compounds with targeted receptor activity. This approach has significantly advanced the understanding of how subtle conformational changes in estrogen receptors can be exploited for therapeutic benefit, especially in hormone-sensitive cancers. Her research has garnered over 15 citations, reflecting its foundational impact on the field. Lappano’s work is notable for bridging computational modeling with experimental validation, offering a paradigm for drug discovery that is both efficient and precise. Her achievements underscore her role as a key figure in translating structural insights into actionable clinical strategies.
Research Focus
Key Achievements
Top Papers
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