Rebekah Jukes
Papers
2
Total Citations
172
H-Index
2
About
Rebekah Jukes is a cell biologist whose research has illuminated critical mechanisms of programmed cell death and cellular signaling. Her most influential work focuses on the molecular architecture and regulation of the apoptosome, a large caspase-activating complex central to mitochondrial-dependent apoptosis. In her highly cited 2004 study (120 citations), Jukes provided foundational insights into how pro-apoptotic proteins released from mitochondria regulate the native Apaf-1/caspase-9 apoptosome complex, detailing its protein composition and caspase-processing activity. This work advanced the understanding of how cells commit to death during development and disease. Beyond apoptosis, Jukes has explored the regulation of Casein Kinase-2 (CK2)—a kinase responsible for up to one-fifth of the eukaryotic phosphoproteome—by inositol phosphates (52 citations). Her contributions have helped clarify how this master regulator of cellular signaling is controlled, with implications for cancer and other proliferative disorders. Through these impactful studies, Jukes has deepened our knowledge of both cell survival and cell death pathways, making her work essential reading for researchers in apoptosis, kinase signaling, and cell fate determination.
Research Focus
Key Achievements
Top Papers
- 1
- 2Regulation of Casein Kinase-2 (CK2) Activity by Inositol Phosphates52 citations · 2004