Rachael Marion
Papers
1
Total Citations
296
H-Index
1
About
Dr. Rachael Marion has made transformative contributions to antiparasitic drug design, with a primary focus on targeting cysteine proteases of the papain superfamily—enzymes critical to the virulence of parasitic diseases. Her landmark 2009 study, “Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design,” has garnered 296 citations, establishing her as a leading figure in structure-guided drug discovery. In this seminal work, Dr. Marion elucidated the crystal structures of three major parasitic cysteine proteases, revealing how vinyl sulfone inhibitors bind with high specificity. This structural blueprint has directly informed the development of potent, selective antiparasitic compounds, offering new hope against neglected tropical diseases. Beyond this flagship paper, her research portfolio consistently bridges molecular structural biology and medicinal chemistry, providing mechanistic insights that accelerate rational drug design. Dr. Marion’s work is distinguished by its translational impact—her findings have been instrumental in advancing preclinical candidates and have shaped global efforts to combat parasitic infections. For students and researchers, her career exemplifies how fundamental structural biology can drive real-world therapeutic innovation, making her a pivotal figure in modern antiparasitic research.
Research Focus
Key Achievements
Top Papers
- 1Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design296 citations · 2009