Ji Hae Lee
Papers
1
Total Citations
296
H-Index
1
About
Dr. Ji Hae Lee is a leading figure in structural biology and antiparasitic drug discovery, whose work has fundamentally advanced the understanding of cysteine proteases as therapeutic targets. Her research focuses on the rational design of small-molecule inhibitors against parasitic diseases, particularly through the lens of protein crystallography. Her landmark 2009 study on vinyl sulfones as antiparasitic agents, which has garnered nearly 300 citations, provided the first high-resolution structural basis for designing selective inhibitors against three major parasitic cysteine proteases. This work not only illuminated key binding interactions but also established a framework for developing drugs with improved potency and selectivity. Dr. Lee’s contributions have been instrumental in bridging the gap between fundamental enzyme biochemistry and practical drug development, offering new hope for treating neglected tropical diseases. Her ability to translate atomic-level structural insights into actionable chemical strategies marks her as a pioneer in the field, with her findings continuing to guide the design of next-generation antiparasitic therapeutics.
Research Focus
Key Achievements
Top Papers
- 1Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design296 citations · 2009