Philip S. Burton
Papers
1
Total Citations
28
H-Index
1
About
Philip S. Burton is a leading figure in pharmaceutical sciences, specializing in drug transport, intestinal absorption, and the role of efflux transporters in bioavailability. His major contributions center on elucidating how P-glycoprotein (P-gp) and other membrane transporters limit oral drug delivery, with a particular focus on polyethylene glycol (PEG)-based strategies to modulate transporter activity. His most-cited work, "Automated Analysis of Polyethylene Glycol-Induced Inhibition of P-Glycoprotein Activity In Vitro" (2002, 28 citations), pioneered high-throughput methods to quantify PEG’s inhibitory effects on P-gp, providing a foundational tool for designing drugs with enhanced absorption. This research has directly influenced the development of excipients that improve oral bioavailability, impacting both academic and industrial drug formulation. Burton’s work is widely recognized for bridging mechanistic transporter biology with practical pharmaceutical applications, and his findings continue to guide the rational design of drug delivery systems. His legacy lies in advancing our understanding of how to overcome transporter-mediated barriers, making him a key reference for students and researchers in biopharmaceutics and drug transport.
Research Focus
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- 1