Philip E. Castle

Papers

Total Citations

H-Index

About

Dr. Philip E. Castle is a leading epidemiologist and molecular biologist whose research has fundamentally shaped our understanding of human papillomavirus (HPV) and its role in cervical carcinogenesis. His work centers on the clinical validation of HPV testing and genotyping methods for cervical cancer screening and prevention. Dr. Castle’s most-cited study, "Comparison of Two PCR-Based Human Papillomavirus Genotyping Methods" (2008, 83 citations), critically evaluated the performance of different molecular assays for detecting individual HPV genotypes and carcinogenic HPV types, providing essential data for standardizing screening protocols. This work, conducted using specimens from the NCI/Costa Rica HPV16/18 vaccine trial, directly informed the development of more accurate, genotype-specific screening tools. Additionally, his investigation into the "Stability of archived liquid-based cytologic specimens" (2003) addressed a critical methodological challenge, demonstrating that long-term storage in methanol-based media can degrade DNA quality—a finding that has guided best practices for biobanking and retrospective molecular studies. Dr. Castle’s contributions have been instrumental in translating HPV biology into effective, evidence-based screening strategies, reducing cervical cancer incidence worldwide.