Natalia Pakharukova

Institute of Biomedical Problems, Russian Academy of Sciences

Papers

Total Citations

H-Index

About

Natalia Pakharukova is a proteomics researcher whose work has illuminated the remarkable plasticity of the human proteome under extreme environmental conditions. Her key research areas include space medicine, physiological adaptation, and the variability of human biofluids under stress. In her most cited study, she investigated how the serum proteome changes during a 7-day “dry” immersion—a ground-based model of microgravity—revealing that even short-term simulated spaceflight triggers measurable shifts in protein expression. She further demonstrated the proteome’s sensitivity to prolonged isolation in a 105-day confinement experiment, showing that urine proteome profiles can serve as non-invasive biomarkers of physiological adaptation. Her systematic analysis of low-molecular-weight serum subproteome across three age groups (20–50 years) established baseline variability in healthy individuals, providing a critical reference for distinguishing pathological changes from normal biological variation. Though her citation counts are modest, her work is foundational for understanding how the human proteome responds to isolation, microgravity, and aging—insights directly relevant to long-duration space missions and personalized health monitoring.