Nancy Jarvis

Papers

Total Citations

215

H-Index

About

Nancy Jarvis is a leading figure in pharmacogenomics and high-throughput genotyping, whose work has been instrumental in enabling large-scale genetic association studies. Her key research areas include single nucleotide polymorphism (SNP) typing, assay automation, and the application of genotyping technologies to complex disease and drug response research. Jarvis’s most notable contribution is her pioneering evaluation of the Invader assay on PCR amplicons, a 2000 study that has garnered over 215 citations. This work demonstrated a genotyping system achieving over 99% accuracy with a failure rate below 5%, establishing a simple, reliable, and flexible platform critical for typing thousands of SNPs across thousands of individuals. By validating this robust, automatable method, Jarvis directly addressed a major bottleneck in pharmacogenetics, paving the way for the large-scale studies that now underpin personalized medicine. Her contributions have provided the foundational technical validation necessary for translating genomic discoveries into clinical applications, making her a key architect of modern, high-throughput genetic analysis.