Naj Sharif
Papers
1
Total Citations
26
H-Index
1
About
Naj Sharif is a leading figure in ocular pharmacology, whose foundational work has advanced our understanding of how prostaglandins regulate intraocular pressure. Her research centers on the molecular mechanisms of adenylyl cyclase signaling in ciliary epithelial cells, a critical pathway for glaucoma therapy. In her most cited study (26 citations), Sharif precisely characterized the EP₂ prostaglandin receptor in human nonpigmented ciliary epithelial cells, demonstrating that specific prostanoid agonists stimulate cyclic AMP production. This work provided the first pharmacological definition of the EP₂ receptor subtype in ocular tissue, establishing a key link between receptor activation and aqueous humor dynamics. By elucidating the distinct signaling profiles of prostaglandin analogs, Sharif’s contributions have directly informed the development of targeted glaucoma treatments. Her rigorous pharmacological approach—combining receptor binding assays with functional cyclic AMP measurements—set a benchmark for studying G-protein-coupled receptors in the eye. Sharif’s research remains a cornerstone for scientists exploring prostaglandin-based therapies, offering a clear roadmap for translating receptor pharmacology into clinical innovation.
Research Focus
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Top Papers
- 1