Michaela Aufderheide
Papers
1
Total Citations
35
H-Index
1
About
Michaela Aufderheide is a pioneering toxicologist whose research has fundamentally advanced the understanding of how cigarette smoke induces genetic damage. Her key contributions center on the development and refinement of in vitro exposure systems that more accurately mimic human inhalation, allowing for precise toxicological assessments of complex aerosols. In her highly cited 2008 study, Aufderheide employed a modified Ames assay to dissect the mutagenicity of native cigarette mainstream smoke, comparing the effects of whole smoke versus its gas/vapour phase across different bacterial tester strains and cigarette types. This work, which has garnered 35 citations, was instrumental in demonstrating that the gas/vapour phase—not just the particulate fraction—possesses significant mutagenic potential, challenging earlier assumptions and reshaping regulatory testing frameworks. Her methodological innovations have been widely adopted in tobacco product evaluation, influencing both academic research and public health policy. Aufderheide’s legacy lies in bridging the gap between laboratory models and real-world exposure, providing critical data for harm reduction strategies and advancing the field of inhalation toxicology.
Research Focus
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Top Papers
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