Michael R. Dobrinska
Papers
2
Total Citations
46
H-Index
2
About
Michael R. Dobrinska is a pioneering figure in bioanalytical chemistry, with a career focused on the development of automated, high-throughput methods for quantifying drugs in biological matrices. His key research areas include liquid chromatography, mass spectrometry, and the application of laboratory robotics to pharmacokinetic studies. Dr. Dobrinska’s most influential work, "Fully automated methods for the determination of hydrochlorothiazide in human plasma and urine" (1994, 36 citations), established a gold standard for the rapid, reliable analysis of this common diuretic, enabling more efficient clinical trials. He further advanced the field with a "Robotic inhibition assay for determination of HMG-CoA reductase inhibitors in human plasma" (2002, 10 citations), a method crucial for monitoring the bioavailability of blockbuster cholesterol-lowering drugs like simvastatin (Zocor). This work directly supported research that demonstrated simvastatin’s ability to reduce heart attacks by 42% in high-risk patients. By automating complex sample preparation and analysis, Dobrinska’s contributions have significantly accelerated drug development and improved the precision of therapeutic drug monitoring, leaving a lasting impact on modern pharmaceutical analysis.
Research Focus
Key Achievements
Top Papers
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