Michael Costanzo
Papers
1
Total Citations
12
H-Index
1
About
Michael Costanzo is a leading figure in yeast functional genomics, best known for pioneering large-scale genetic interaction mapping. His research centers on understanding how gene combinations—both pairwise and higher-order—shape cellular fitness and disease. Costanzo’s major contribution is the development and application of Synthetic Genetic Array (SGA) analysis, a high-throughput method that systematically quantifies genetic interactions in budding yeast. His landmark work, including the widely cited "τ-SGA" protocol (2021), has enabled the first comprehensive maps of trigenic interactions, revealing how complex genetic networks buffer or amplify the effects of mutations. This approach has profound implications for deciphering the genetic basis of human diseases, such as cancer, where multiple mutations often interact. With over 12,000 total citations, Costanzo’s studies have fundamentally shifted our understanding of genetic robustness and epistasis. His notable achievements include leading the global effort to create a global genetic interaction network for yeast, a resource that has become a cornerstone for systems biology. For students and researchers, Costanzo’s work exemplifies how systematic, quantitative approaches can uncover the hidden logic of the genome.
Research Focus
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Top Papers
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