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About

Michael C. Jewett is a pioneering leader in synthetic biology, whose research bridges the gap between fundamental biochemistry and real-world applications. His key contributions lie in cell-free metabolic engineering and the development of portable diagnostic technologies. Jewett’s work on controlling cell-free metabolism through physiochemical perturbations, a study cited over 80 times, has provided foundational insights into how to manipulate biological systems outside of living cells, enabling precise and scalable production of chemicals and proteins. More recently, his team has advanced the semiautomated production of cell-free biosensors, a breakthrough with over 10 citations that promises to revolutionize point-of-need diagnostics. These freeze-dried sensors can detect toxins and human health biomarkers, offering a stable, distributable alternative to conventional lab tests. Jewett’s impact is profound: his innovations are not only advancing fundamental understanding but also creating deployable tools for global health and environmental monitoring. His work exemplifies how synthetic biology can be translated into practical, life-saving technologies.