Matthew P. DeLisa

Papers

Total Citations

H-Index

About

Dr. Matthew P. DeLisa is a pioneering figure in protein engineering and synthetic biology, best known for his transformative work on glycoprotein engineering and recombinant protein secretion in *E. coli*. His research has fundamentally advanced the understanding and application of bacterial glycoengineering, enabling the production of complex therapeutic glycoproteins in prokaryotic hosts—a breakthrough with profound implications for biopharmaceutical manufacturing. Among his notable contributions, DeLisa developed innovative survival-selection assays for extracellular protein expression, as exemplified by his 2017 study on hypersecretory phenotypes, which has garnered 24 citations and opened new avenues for high-yield protein production. His lab’s work on the bacterial N-linked glycosylation pathway has been highly influential, with several papers cited over 100 times, collectively shaping the field of glycoengineering. DeLisa’s achievements include being a Fellow of the American Institute for Medical and Biological Engineering (AIMBE) and receiving the National Science Foundation CAREER Award. His research continues to bridge fundamental molecular biology with practical applications, making him a key resource for students and researchers interested in protein design, metabolic engineering, and biotherapeutics.