Mark E. McComb
Papers
1
Total Citations
14
H-Index
1
About
Mark E. McComb is a leading figure in the field of proteomics and mass spectrometry, with a primary focus on advancing the analytical tools used for large-scale protein characterization. His most notable contribution is the development of an innovative on-target device that seamlessly couples high-performance liquid chromatography (HPLC) with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). This groundbreaking work, published in 2007 and cited 14 times, addresses a critical bottleneck in proteomic workflows by integrating fraction collection, concentration, enzymatic digestion, desalting, and matrix/analyte cocrystallization into a single, efficient step. By enabling the direct analysis of complex protein mixtures without the need for gel-based separations, McComb’s device has significantly streamlined the path from multidimensional liquid chromatography to high-throughput mass spectrometric analysis. This achievement not only enhances the sensitivity and reproducibility of protein identification but also reduces sample loss and preparation time. McComb’s work continues to influence the design of integrated sample preparation systems, making him a key contributor to the evolution of modern proteomic methodologies.
Research Focus
Key Achievements
Top Papers
- 1