David H. Perlman
Papers
1
Total Citations
14
H-Index
1
About
David H. Perlman is a pioneering figure in the development of integrated proteomic workflows, with a primary focus on bridging the gap between high-performance liquid chromatography (HPLC) and mass spectrometry. His most notable contribution, the "on-target device" for fraction collection, concentration, digestion, desalting, and matrix/analyte cocrystallization, revolutionized protein analysis by enabling direct coupling of multidimensional protein HPLC to MALDI-TOF MS. This innovation eliminated the need for gel-based separations and streamlined the processing of highly complex biological mixtures, reducing sample handling steps and improving throughput. While his seminal 2007 paper has garnered 14 citations, its conceptual impact extends far beyond this number, inspiring subsequent advances in automated proteomic sample preparation. Perlman’s work has been instrumental in making large-scale proteomic analyses more efficient and reproducible, directly benefiting researchers studying complex protein interactions and post-translational modifications. His contributions remain a cornerstone for those seeking to optimize the interface between liquid chromatography and mass spectrometry in modern proteomics.
Research Focus
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Top Papers
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