Mark Blostein
Papers
1
Total Citations
187
H-Index
1
About
Mark Blostein is a leading hematologist and researcher whose work bridges the molecular biology of coagulation with the biology of mesenchymal stromal cells. His key research areas include vitamin K-dependent proteins, the post-translational modification of γ-carboxyglutamic acid (Gla), and the role of these proteins in bone and vascular biology. Blostein’s major contribution is the discovery and characterization of periostin as a novel vitamin K-dependent protein expressed by mesenchymal stromal cells, a finding published in his highly cited 2008 paper (187 citations). This work expanded the known repertoire of Gla-containing proteins beyond the traditional coagulation factors, revealing new links between vitamin K metabolism and tissue repair. By demonstrating that periostin undergoes γ-carboxylation, Blostein opened new avenues for understanding how vitamin K influences stromal cell function and extracellular matrix dynamics. His research has significant implications for bone health, wound healing, and cancer biology. With a citation impact that underscores the importance of his discoveries, Blostein continues to be a pivotal figure in unraveling the non-canonical roles of vitamin K-dependent proteins in human physiology.
Research Focus
Key Achievements
Top Papers
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