Mariusz G. Fleszar
Papers
3
Total Citations
34
H-Index
2
About
Mariusz G. Fleszar is a leading researcher in colorectal cancer (CRC) biology, with a focus on the molecular mechanisms underlying surgical stress, immunity, and tumor progression. His work has significantly advanced the understanding of how metabolic and endocrine pathways influence patient outcomes. A key contribution is his investigation of the L-Arginine/NO pathway, where he demonstrated its diagnostic and prognostic value in CRC using tandem mass spectrometry in a cohort of 199 individuals, including 137 cancer patients. This study, with 23 citations, identified novel biomarkers for adverse clinical outcomes following surgery. Dr. Fleszar has also pioneered research on the impact of surgical technique on patient physiology. His work on cortisol dynamics revealed that sex, type of surgery, and surgical site infections are critical factors influencing perioperative stress responses in CRC patients. Most notably, his recent 2025 study shows that robot-assisted colorectal surgery mitigates early postoperative immunosuppression and angiogenesis compared to open surgery, offering a molecular rationale for minimally invasive approaches. With a growing citation record, Dr. Fleszar’s research is shaping personalized surgical care and biomarker-driven management in colorectal oncology.
Research Focus
Key Achievements
Top Papers
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