Manuela Bieri
Papers
1
Total Citations
124
H-Index
1
About
Manuela Bieri is a pioneering figure in the field of three-dimensional (3D) cell culture and tissue engineering, with a focused expertise in developing scalable, scaffold-free microtissue models for drug discovery. Her most cited work, a 2011 study on automated production and drug sensitivity testing using spherical tumor microtissues (124 citations), addresses a critical bottleneck in translational research: bridging the gap between academic 3D culture methods and industrial high-throughput applications. Bieri’s major contribution lies in designing robust, reproducible protocols that enable the formation of scaffold-free tumor spheroids, which better mimic in vivo tumor microenvironments than traditional 2D monolayers. This innovation has profound implications for drug sensitivity testing, allowing for more accurate predictions of therapeutic efficacy and resistance. Her research has been instrumental in demonstrating that 3D microtissues can be integrated into automated workflows, paving the way for their adoption in pharmaceutical screening pipelines. By tackling the practical challenges of scalability and consistency, Bieri has helped shift the paradigm toward physiologically relevant models in preclinical testing, making her work a cornerstone for researchers seeking to improve the translational success of cancer therapeutics.
Research Focus
Key Achievements
Top Papers
- 1